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Israel launched聽聽on Friday that聽聽and military sites, killing at least two top聽聽and raising the prospect of an all-out war between the two bitter Middle East adversaries. It appeared to be the most significant attack Iran has faced since its 1980s war with Iraq.

The strikes came amid simmering tensions over Iran鈥檚 rapidly advancing nuclear program and appeared certain to trigger a reprisal. Hours later, Israel鈥檚 military said it had begun intercepting Iranian drones launched in retaliation.

The U.S. is shifting military resources in the Middle East in response to Israel strikes and possible Iran retaliation, officials say.

What to know

Israel targeted Iran鈥檚 nuclear sites:聽Israeli Prime Minister聽聽said that Israel targeted Iran鈥檚 main enrichment facility in Natanz and the country鈥檚 ballistic missile program.

General Hossein Salami was killed:聽聽was confirmed dead, Iranian state television reported, as Supreme Leader Ayatollah Ali Khamenei said other top military officials and scientists were also killed.

Both sites have been the focus of Trump鈥檚 nuclear deal negotiations:聽聽that he warned Netanyahu against launching an attack on Iran鈥檚 nuclear facilities while diplomatic efforts were underway. On Friday, he again urged Iran to reach a nuclear deal with US, warning attacks 鈥榳ill only get worse!鈥�

The attack pushes the region into a new and uncertain phase:聽The deaths of top Iranian officials also marks a significant blow to Tehran鈥檚 governing theocracy and an immediate聽.

Oil prices are leaping and stocks are falling after Israel鈥檚 attack on Iran

Markets are worried that Israel鈥檚 attack could escalate further and damage the flow of crude around the world, along with the global economy.

The S&P 500 was down 0.7% in early trading Friday and on track for its worst day in more than two weeks. The Dow Jones Industrial Average was down 423 points, or 1%, and the Nasdaq composite was down 0.8%.

The price of a barrel of benchmark U.S. crude jumped 7.3%. Iran is one of the world鈥檚 major producers of oil.

Turkey suspends flights to Iran, Iraq, Syria and Jordan

Turkish Airlines and other local airline operators suspended flights to those countries until Monday due to security concerns, the country鈥檚 transportation minister, Abdulkadir Uraloglu, announced on X.

Iraq complains to UN about Israel using its airspace to attack Iran

Early Friday morning, many in Iraq reported hearing warplanes and sounds of explosions that were believed to be the firing of missiles from Iraqi airspace.

The government of the semi-autonomous Kurdish region in northern Iraq 鈥� which has a close relationship with the United States 鈥� also issued a statement condemning Israel鈥檚 strikes on Iran.

Egyptian and German foreign ministers warn against regional escalation

Speaking to reporters in Cairo, Egyptian Foreign Minister Badr Abdelatty condemned the 鈥渄angerous and unjustified鈥� escalation in light of Israel鈥檚 attacks on Iran, warning it could plunge the region into chaos.

Meanwhile, his German counterpart Johann Wadephul expressed concern over Israel鈥檚 military strikes and Iran鈥檚 retaliatory launch of hundreds of drones toward Israel, calling the developments deeply worrying.

Abdelatty affirmed that nuclear non-proliferation is among top Egyptian policy priorities. Wadenphul, meanwhile, raised concerns about Iran鈥檚 nuclear program.

Netanyahu calls allied leaders in Germany, India and France

A statement from Israeli Prime Minister Benjamin Netanyahu鈥檚 office said 鈥淭he leaders expressed understanding for Israel鈥檚 defense needs against the threat of Iranian annihilation.鈥�

He was expected to speak with Trump, Putin and Starmer later in the day. Israel鈥檚 Foreign Minister Gidon Saar was also reaching out to European leaders throughout the day.

Israeli intelligence had 鈥榓bsolutely exceptional鈥� knowledge of Iran鈥檚 nuclear program, expert says

The strikes showed Israel knew the private addresses of key military leaders and combined that with the ability to hit targets 鈥渨ith precision,鈥� delivering 鈥渁 tremendous amount of damage鈥� to the nuclear program, said Fabian Hinz, a defense and nuclear expert at the International Institute for Strategic Studies in London.

Hinz suggested there are two main ways Iran could respond — by using Hezbollah and air attacks — but indicated both options are limited.

Hezbollah, he said, 鈥渋s no longer in a position鈥� to fulfill its role as Iran鈥檚 forward deterrence after repeated attacks from Israel. There are also questions about the effectiveness of Iran鈥檚 missiles, which were largely intercepted during attacks on Israel last year, he said.

Iran calls for emergency Security Council meeting

Iran鈥檚 U.N. Mission said it has asked for an emergency meeting of the Security Council following the Israeli attacks.

The emergency session is likely to take place Friday afternoon, the mission said.

Turkey鈥檚 Erdogan calls Israeli strikes a blatant provocation

Turkish President Recep Tayyip Erdogan has called Israel鈥檚 strikes on Iran a 鈥渂latant provocation鈥� that violates international law.

In a statement posted on X, Erdogan suggested that the attack was an attempt to divert attention away from Israel鈥檚 ongoing actions in Gaza.

鈥淭he attacks by (Israeli Prime Minister Benjamin) Netanyahu and his network of massacre that are igniting our entire region must be prevented,鈥� Erdogan wrote.

Israel told Trump administration of attacks ahead of time

Israel told the Trump administration that large-scale attacks were coming and expected Iranian retaliation would be severe, U.S. officials said, leading the United States to order the evacuations of some nonessential embassy staffers and authorize the voluntary departure of military dependents in the region.

The officials were speaking on condition of anonymity to describe private diplomatic discussions.

Special envoy Steve Witkoff still plans to go to Oman this weekend for talks on Tehran鈥檚 nuclear program, but it鈥檚 not clear if the Iranians would participate, officials said.

Macron calls for all parties to be restrained

French President Emmanuel Macron has called on ” all parties to exercise the utmost restraint and de-escalate鈥� in order 鈥渘ot to jeopardize the stability of the entire region鈥� in a post on X.

Macron, who held an emergency security meeting on Friday morning following Israel鈥檚 strikes on Iran, said France is taking all necessary measures to protect its nationals, diplomatic sites and military bases in the region.

Macron said he spoke with U.S. President Donald Trump as well as leaders of Saudi Arabia, Jordan, United Arab Emirates, Qatar, Germany and Britain about the latest developments.

Hamas expresses solidarity with Iran

鈥淲e declare our solidarity with the Islamic Republic of Iran in the face of the brutal Zionist aggression, which primarily stems from Iran鈥檚 support for the Palestinian people and its significant backing of their honorable resistance fighters,鈥� said Abu Ubaida, spokesperson for Hamas鈥檚 armed wing.

He also mourned the deaths of senior Iranian leaders and others killed in the strike, condemning the attack as 鈥渃owardly.鈥�

Trump: 鈥楽econd chance鈥� for Iran

In a further post on the Truth Social platform, President Donald Trump added: 鈥淭wo months ago I gave Iran a 60 day ultimatum to 鈥榤ake a deal.鈥欌��

鈥淭hey should have done it! Today is day 61. I told them what to do, but they just couldn鈥檛 get there. Now they have, perhaps, a second chance!鈥� he wrote Friday.

Trump calls Israeli strikes on Iran 鈥榚xcellent鈥� and says 鈥榤ore to come鈥�

In an interview with ABC News, U.S. President Donald Trump called the Israeli strikes on Iran 鈥渆xcellent鈥� and previewed more attacks.

鈥淚 think it鈥檚 been excellent. We gave them a chance and they didn鈥檛 take it,鈥� Trump told ABC on Friday morning. 鈥淭hey got hit hard, very hard. They got hit about as hard as you鈥檙e going to get hit. And there鈥檚 more to come, a lot more.鈥�

This is a developing story, check back for updates